Endocrine Abstracts

Introduction: Type IV Renal Tubular Acidosis (Type 4 RTA) is an underdiagnosed condition known to be more frequent in Diabetes Mellitus patients with moderate renal impairment. It is thought to be very common, with an incidence of 3.8% of hospital admissions in some series, being an increasing problem among the elderly and aggravated by polypharmacy.Methods/design: The authors describe 4 cases of Type 4 RTA associated with type 2 Diabetes diagnosed and f...

Introduction: Pituitary surgery is currently considered the preferred treatment for Cushing’s disease (CD) and achieves remission in 55–85% of patients. Cortisol falls quickly after surgery, so that early post-operative cortisol level has been used as predictor of remission. There’s no agreement about optimal timing for cortisol measurement, with wide variability between centres.Objective: To assess the value of early post-operative serum ...

Introduction: Cushing’s disease (CD) is characterised by pathologic hypercortisolism caused by an ACTH-secreting pituitary adenoma. The primary modality for definitive treatment is pituitary surgery. The rarity of CD has made it difficult to establish reliable predictive factors of outcomes.Aim: Assessment of clinical, hormonal, radiological, surgical and histological findings as predictors of remission and relapse of CD.Metho...

Introduction: We wanted to analyse the descriptive variables of a series of 1567 thyroidectomy patients between 2010 and 2013 and its association with malignancy in our series.Material and methods: Retrospective, multicentre study done by review of the medical records of 1567 patients who became thyroidectomy between 2010 and 2013 in eight sanitary areas. This is an analysis of clinical and demographic variables.Results: The percen...

Introduction: We wanted to analyse the pathology results of thyroidectomies performed in the hospitals of Castilla La Mancha (Spain) between the years 2010 and 2013, inclusive.Material and methods: A retrospective, multicentre, descriptive study of the histopathological results of the 1567 thyroidectomies performed in the hospitals of the eight health districts in our region between the years 2010 and 2013.Results: The histopatholo...

Introduction: Atypical pituitary adenomas have higher risk of aggressive behaviour in particular by the higher growth, local invasion and high risk of recurrence after surgery. In acromegaly the resistance to somatostatin analogues may be another manifestation of these adenomas since higher levels of Ki-67 are associated with poor response to therapy.Case report: A 41-year-old woman presented to our consult with history of headaches, growth of the hands,...

Introduction: Lithium therapy is commonly used in bipolar disorder treatment. Alongside the increasing prevalence of goiter and hypothyroidism, the sustaining use of lithium therapy is associated with several metabolic disorders, such as hypercalcemia and hyperparathyroidism (HPT).Case report: A 64-year-old woman with history of bipolar disorder treated with lithium for several years was referred to our department for evaluation of recurrent hypercalcemi...

Background: Recent reports suggest that female sex could be an indicator of better response to liraglutide in patients included in clinical trials.Aim: To compare efficacy of liraglutide in women and men with type 2 diabetes mellitus (T2DM), in real clinical practice.Patients and methods: Our study included 116 patients with T2DM and obesity (BMI >30) attending outpatient clinic, which initiated with liraglutide (0.6 mg/daily f...

Introduction: Abnormalities in cell cycle pathways, such as CDKN1B (p27) underexpression, have been identified in the pathogenesis of pituitary adenomas, but their underlying mechanisms have not been elucidated. Ribosomal proteins have been recently related to pituitary tumorigenesis. In gastric cancer, RPS13 down-regulates p27 and promotes cell cycle progression; these mechanisms have not yet been explored in pituitary adenomas.Objective: To evaluate th...

Introduction: Generously supported by IPSEN)-->Treatment with recombinant ST is subject to strict criteria. Differences in the response to therapy based on the maximum level of ST in diagnostic tests (ST ≤5 vs ST >5 ng/ml), could predict whose patients would benefit more from therapy.Purpase: Assess differences in the response to therapy with rST in patients with IDGH.Methods: S...